Hi,
if you are not using XPages applications on the server, you can remove the directory without any problems.
But if not, I think this is not a good idea, because this is the directory where the XPages are persisted.
Maybe you can change the path to another directory. Just change the property xsp.persistence.dir.xspstate in the xsp.properties-file of the server.
You can change the upload path xsp.persistence.dir.xspupload and attachement storage xsp.persistence.dir.xsppers.
Hope this helps
Sven
http://blog.hasselba.ch