I had a customer who used iQ.Suite:

https://www.gbs.com/en/email-management

It has a lot of functions and allows you to use multiple scanning engines and create your own file fingerprints.

I have had very good experience with Spamsentinel:

http://www1.maysoft.com/

We're about to purchase ESET, going away from SMSDOM. Two things that I liked about ESET - price and that no Domino side configuration was needed besides an add-on task. Everything can be configured in Windows application.

Using Eset, very happy for monitoring internal email along with another product at the gateway.

Scans SMTP and NRPC mail .. very nice

Thanks everybody for your recommendations!

So far I have tested IQ Suite and ESET. Both are very powerful in their own way but they work differently.

IQ Suite is a set of Domino NSF:s with a lot of settings and interesting stuff, like 4 different scan engines (Kaspersky, Sofos etc).

ESET is more of a Windows application with a Domino server probe.

Both tools could easily be managed and did not take any big amount of resources on the server. I think the one with the best price will be bought.

Most of the user using Quick heal Antivirus security to protect the Domino server. As it has a lot of advanced features with the regular update, from Quick Heal Antivirus Customer Service you will get the details information on it, and if you need any support, you can get help form it.