IBM Domino Collaboration Express
I think IBM Client Application Access is the name for the client on Windows 10. It will open non-mail databases locally and behaves like a notes client in every respect except an attempt to open the mail database is passed off to iNotes.
This does not seem to be configurable. There is a hack to prevent it, I haven't tried, putting garbage in the connection document for the mail file field. That breaks various other things, as you can imagine.
How about a check box in the connection document to allow local access??? I gather this won't be allowed because the fat client isn't being provided with policy enforcement capability and this has to be passed off to the server via iNotes so it would need to be authorised maybe in the Domino Directory person document.