Thanks for the response John, that is a good suggestion.
Since I was only having a problem with this one application I ruled out a settings or permission based issue. To make a long story short, since the issue seemed to have occurred after I created a new replica and saved over the old one I decided to try and reboot the server that the application was on. Surprisingly enough after the server came back up the problem was fixed. That was the first time I've run into that issue in over 10 years supporting the platform, go figure.