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If you have a Lotus/IBM business partner that you work with, you probably want to engage them to look at your infrastructure as it is now and offer suggestions. You may benifit greatly from thier experience and expertise.
In moving to VM you might face sizing issues if you support large numbers of users.
With SAN storage, you'll want to configure your LUNs to limit the possiblity of disk contention.
There are also questions about Fiber Channel versus iSCSI connectivity.
Below is a link to a best practices doc from IBM regarding SAN storage.
Besides this site, you may also find useful information on http://www.planetlotus.org. It's a link to the blogs of various IBMers, IBM/Lotus Business Partners and other Lotus professionals.
Feedback response number WEBB85DPVQ created by ~Dan Nimkroster on 05/12/2010