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Symantec Mail Security: We use it and I don't like it.
Regarding your concerns about SMS handing SPAM, etc., I'd recommend getting some sort of special-purpose email server to act as a gateway to your internal email--and having your Domino server tucked safely behind a firewall, using the gateway as a "smart host" to deliver email to/from the internet.
There are a number of these devices around from a variety of vendors (or, you could configure one on Linux, Windows, etc. using something like Sendmail, EXIM, etc.).
By doing this, you're offloading a lot of the SPAM garbage before it gets to the Domino server...plus the special purpose systems/devices are focused on email security as their primary function--and they will do virus scanning, spam blocking, white/black listing, TLS encryption (if desired), etc.
That also lets you put the Domino Server behind a protected firewall...which greatly limits the access people have to your Domino server and all the ports/services/etc. (and, thus, should greatly reduce your risk to security vulnerabilities and pesky snooping/poking against your Domino server).
Feedback response number WEBB7ZQQE5 created by ~Sarah Cistoomarader on 01/15/2010